18 May
2023
Leveling Health Inequalities: Raising the School Leaving Age Reduces the Risk of Diseases and Severe Medical Conditions Related to Genetic Endowment
Health inequality has a significant genetic component and socio-economic factors, including education, can moderate the effects of genes. However, little is known about whether more years of education can effectively moderate the relationship between genetic conditions and severe contemporary diseases and medical conditions. I use UK Biobank data to investigate the relationship between education, genetic endowment, and four health conditions: heart attack, cancer, stroke, and type-2 diabetes. To avoid the potential endogeneity of education, I focus on the long-term health consequences of a 1972 increase in the UK school-leaving age (ROSLA). As a measure of genetic endowment, I use an index of genetic predispositions for obesity. Genetic predispositions are typically summarised by a weighted average of individual genetic markers called polygenic scores (PGS), where weights are derived from analyses performed on different populations. Furthermore, the outcomes of these analyses often differ from the outcomes the PGS is used to predict. This may skew the results of follow up studies of other outcomes, including cancer. I introduce a two-step method that adjusts the available weights to new outcomes, and show that genetic predisposition for obesity increases the risks of the four diseases I study. The results based on my new method show that the additional year of schooling driven by the ROSLA reform diminished the importance of genetic predispositions for the risks of cancer and heart attack by 40%. The results offer new evidence on how environments moderate the inequalities in health that have been tilted from birth.